Replying to a message from: Bob

Is there a way to reject any e-mails addressed to unexisting or invalid email addresses on my domain\exchange server

or can I just add the 3 good valid email addresses that I would like passed thru Xeams 

I only use Xeams for incoming mail spam filtering and get a lot of spam trying to get through made up users @mydomain.com

Thanks for your support

Bob